Kinetic Isotope Effects in the Nucleophilic Substitution Reactions of Benzyl- and 1-Phenylethyl -benzenesulfonates with Deuterated Aniline Nucleophiles

Kinetic Isotope Effects in the Nucleophilic Substitution Reactions of Benzyl- and 1-Phenylethyl -benzenesulfonates with Deuterated Aniline Nucleophiles

Primary and secondary ${\alpha}$-deuterium kinetic isotope effects are determined with deuterated aniline nucleophiles in the nucleophilic substitution reactions of benzyl benzenesulfonates and 1-phenylethyl benzenesulfonates in acetonitrile at 30.0^{\circ}C. The $k_H/k_D$ values support our previous conclusions regarding the transition state structures proposed for the two reactions based on the cross-interaction constants ${\rho}_{ij}$; the former is a typical $S_N2$ reaction whereas in the latter the four-center transition state may be involved.

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