국가지식-학술정보
PHENOTYPING OF PHENYTOIN TREATED RAT LIVER CYTOCHROME P-450 WITH MONOCLONAL ANTIBODIES
PHENOTYPING OF PHENYTOIN TREATED RAT LIVER CYTOCHROME P-450 WITH MONOCLONAL ANTIBODIES
- 한국독성학회
- Toxicological Research
- Vol.7 No.1
-
1991.011 - 12 (12 pages)
- 0
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The phenotyping of cytochrome P-450 in hepatic mivrosomes induced by phenytoin in the rats was carried out by using several monoclonal antibodies (MAbs) against specific P-450 isozymes. Phenytoin (180 mg/kg) was administered intrapritoneally for three consecutive days to the male Sprague-Dawley rats(100-120g). Solid phase radio-immunoassay showed higher binding affinity of MAb PB 2-66-3 and PCN 2-13-1 to the microsomes from phenytoin treated rats than those to from untreated rats, which was comparable to the level in phenobarbital induced rat hepatic microsomes.
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