The Synthetic Utilization of 2-Hydroxymethyl-2,5-dihydrothiophene 1,1-Dioxide in the Intramolecular Diels-Alder Reaction

The Synthetic Utilization of 2-Hydroxymethyl-2,5-dihydrothiophene 1,1-Dioxide in the Intramolecular Diels-Alder Reaction

2-Hydroxymethyl-2,5-dihydrothiophene 1,1-dioxide (1) was prepared from thiophene-2-carboxylic acid by consecutive reactions involving the Birch reduction, esterification, reduction with lithium aluminum hydride, and oxidation with Oxone$^{\circledR}$. The esterification of alcohol 1 with various unsaturated carboxylic acids provided the precursors 8 for the intramolecular Diels-Alder reaction. The cheletropic expulsion of sulfur dioxide from the esters 8 followed by intramolecular Diels-Alder reaction furnished bicyclic ${\gamma}$-and ${\delta}$-lactones.

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