국가지식-학술정보
A Single Nucleotide Polymorphism in Transforming Growth Factor-$\beta$ type II Receptor of the Rat
A Single Nucleotide Polymorphism in Transforming Growth Factor-$\beta$ type II Receptor of the Rat
- 한국독성학회
- Toxicological Research
- Vol.16 No.1
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2000.0159 - 61 (3 pages)
- 0
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A single nucleotide polymorphism in the transforming growth factor-$\beta$ type II receptor (TGE$\beta$RII) gene of the rat was studied. TGF$\beta$RII is a tumor suppressor that is frequently inactivated by mutation in human colon cancers. A novel nucleotide polymorphism of G to A(or A to G), which causes a silent mutation at codon 129, was found in G:C rich sequence in the TGF$\beta$RII gene of Sprague-Dawley rats. The results suggest that genetic polymorphism occures without a strain of the laboratory animal.
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