국가지식-학술정보
The Study of Doxorubicin and its Complex with DNA by SERS and UV-resonance Raman Spectroscopy
The Study of Doxorubicin and its Complex with DNA by SERS and UV-resonance Raman Spectroscopy
- 대한화학회
- Bulletin of the Korean Chemical Society
- Vol.25 No.8
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2004.011211 - 1216 (6 pages)
- 0
커버이미지 없음
The interaction of the antitumour agent doxorubicin with calf thymus DNA is investigated in an aqueous solution at a pH level of 6-7 with molar ratios of 1/10. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the doxorubicin binding sites and the structural variations of doxorubicin-DNA complexes in an aqueous solution. Doxorubicin intercalates with adenine and guanine via a hydrogen bond formation between the N7 positions of purine bases and the hydroxyl group of doxorubicin.
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