키토산 올리고당의 암예방 효과

Chitosan Oligosaccharides (COS), COS I (M.W.: 3,000-5,000 daltons) and COS Ⅱ (M.W. : 1,000-3,000 daltons), were tested for their chemopreventive potentials using three biochemical markers of carcinogenesis such as Quinone reductase, glutathione S-transferase and glutathione. COS Ⅰ and COS Ⅱ were potent inducers of Quinone reductase activity in murine hepatoma cells (Hepalclc7). Glutathione S-transferase activity was increased about 1.5 fold with COS Ⅱ in cultured murine hepatoma cells. In addition glutathione levels were slightly increased with COS Ⅰ. These results suggest that Chitosan Oligosaccharides has a chemopreventive potential by inducing Quinone reductase and glutathione S-transferase activities and increasing glutathione levels.