신세포암에서 신생혈관형성, 간세포 성장인자 및 c-met 발현이 예후에 미치는 영향

Purpose: The purpose of this study was to evaluate the prognostic significance of tumor angiogenesis and angiogenic factors such as hepatocyte growth factor (HGF) and c-met in renal cell carcinoma.<BR> Materials and Methods: Immunohistochemical staining on HGF, c-met expression and angiogenesis was performed in 35 renal cell carcinoma tissues and 18 benign renal tissues. HGF and c-met were identified with specific corresponding antibodies. Cases were considered positive when HGF and c-met expression were seen in more than one third of cells. To evaluate the angiogenesis, the microvessels were determined by anti-CD31 immunohistochemistry. We compaired HGF, c-met and microvessel count with clinicopathologic characteristics such as stage, nuclear grade and histology in renal cell carcinoma.<BR> Results: Among 35 patients with renal cell carcinoma, 16 patients (45.7%) showed positive stain for HGF and c-met. HGF, c-met overexpression and microvessel count were significantly correlated with tumor stage and nuclear grade of renal cell carcinoma (p＜0.05), but not correlated with cell type of renal cell carcinoma.<BR> Conclusions: This results suggested that both HGF and c-met overexpression and angiogenesis measured by microvessels count could be significant prognostic indicators of renal cell carcinoma.