인체 신세포암에서 Hypoxia Inducible Factor-1α 및 Vascular Endothelial Growth Factor 발현과 병리학적 특징과의 관계

Purpose: HIF-1α (Hypoxia inducible factor-1α) and VEGF (vascular endothelial growth factor) have been reported to be involved in tumor growth and metastasis, but only a little data on the roles of HIF-1α and VEGF in renal cell carcinomas are available, and few studies have yet evaluated their prognostic values. The aim of the present study was to assess the HIF-1α and VEGF expression and evaluate the relationships between HIF-1α/VEGF and the histopathological characteristics in renal cell carcinomas.<BR> Materials and Methods: HIF-1α and VEGF immunohistochemical stainings were performed on formalin-fixed, paraffin-embedded archival tissues from 22 renal cell carcinoma tissues and 13 normal kidney tissues, used as a control group. The interpretation of the immunohistochemical stainings were semi-quantitatively performed by one pathologist.<BR> Results: The expressions of HIF-1α and VEGF were significantly higher in the patient than the control group. The HIF-1α and VEGF expressions were correlated to each other, and inclined to be positively correlated with the pathological stage and grade of the renal cell carcinoma.<BR> Conclusions: The HIF-1α and VEGF expressions might be independent predictors of the outcome, as well as the stage and grade of renal cell carcinomas. This study suggests that HIF-1α and VEGF may be potential prognostic factors in renal cell carcinomas.