대장 및 직장암의 간전이 시 간절제와 고주파 온열치료의 임상적 비교

Purpose: The aim of this study was to compare the clinical characteristics between hepatic resection and radiofrequency ablation (RFA) in hepatic metastases of colorectal cancer.<BR> Methods: Among 183 patients who were diagnosed as having colorectal cancer with hepatic metastases from May 1999 to Dec. 2002, excluding 56 patients who did not undergo a hepatic resection or RFA due to multiple hepatic metastases or other distant metastases, 127 patients who were treated with a pure hepatic resection (N=68), pure RFA (N=35), or a hepatic resection with RFA (N=24) synchronous or metachronous were reviewed in this study. The study included metastatic hepatic tumor size, number, distribution, disease-free survival rate, and overall survival rate.<BR> Results: The mean hepatic tumor sizes in the resection group, the RFA group, and the resection with RFA group were 3.3 ㎝, 3.0 ㎝, and 2.5 ㎝, respectively, but the differences in the sizes had no statistical significance (P＞ 0.1). In the view of the number of hepatic metastases, single metastases were the most prevalent kind in the resection group and the RFA group (64.7％ and 60.0％) while multiple metastases were the most prevalent kind in the resection with RFA (20/24, 83.3％). In the re-section and the RFA groups, a unilobar distribution was the most common (88.2% and 68.6%), but a bilobar distribution was the most common (87.5%) in the resection with RFA group. The disease-free survival rates were 42.2％ (resection group), 30.7％ (RFA group), and 22.2% (resection with RFA group) in the third year (P=0.65). The overall survival rates were 70.9％ (resection group), 68.4％ (RFA group), and 62.9％ (resection with RFA group) in the third year (P=0.19).<BR> Conclusions: There were no significant statistical differences in the disease-free survival and the overall survival rates between the three groups. Radiofrequency ablation (RFA) is considered as not only a complementary but also an alternative treatment tool to hepatic resection in the treatment of hepatic metastases of colorectal cancer and has a similar survival rate.