폐절제술을 시행한 대장직장암의 폐전이 환자에서 예후예측인자와 생존율 분석

Pupose: Pulmonary metastases occur in up to 10% of all patients who undergo a curative resection for colorectal cancer. Surgical resection is an important part in the treatment of pulmonary metastasis from colorectal cancer. We analyzed the treatment outcome and the prognostic factors affecting survival in this subset of patients. Methods: Between a curative resection for pulmonary metastases from clorectal cancer. Uncontrollable synchronous liver and lung metastasis or synchronous colorectal cancers with isolated lung metastasis were excluded from this study. A retrospective review of the patients` characteristics and of factors influencing survival was performed. Survival was analyzed by using the Kaplan-Meier method. Comparisons between the groups were performed by using a log-rankanalysis and the Cox proportional hazard model. Results: The 5-year overall survival rate of all patients who received a pulmonary resection was 50.3%. The number of pulmonary metastases was significantly related with survival monary metastases was significantly related with survival(P=0.032). A pre-thoracotomy CEA level exceeding 5 ng/ml was related with poor survival(P=0.001). A disease-free interval of greater than 2 years did not correlate with survival after a thoracotomy (P=0.3). Conclusions: The pre-thoracotomy CEA level and the number of metastases were independent prognostic factors. Resection of a pulmonary metastasis from colorectal cancer may result in improved survival or even cure in selected patients. A pulmonary resection of colorectal cancer is regarded as a safe and effective treatment with low mobidity and mortality rates. J Korean Soc Coloproctol 2007;23;53-59