Alcohol dehydrogenase (ADH; EC. 1.1.1.1) and aldehyde dehydrogenase (ALDH; EC 1.2.1.3) play important roles in the metabolism of both endogenous and exogenous alcohols and aldehydes. This study was designed to investigate biological effects of chitooligosaccharide (COS) on alcohol metabolism in Sprague-Dawley (SD) rats after acute ethanol intake. Animals were submitted to an acute intake of excess ethanol (3 g/㎏ body weight), and blood of each rat was collected at 1, 3, 5, and 8 h after ethanol administration. After the administration of EtOH, blood alcohol concentration (BAC) in COS-treated group was decreased speedily compared to control group treated only ethanol in a dose-dependent manner. Moreover, activities of ADH and ALDH were increased by COS intake. In the present study, it is suggested that COS intake could give an influence upon the reduction of BAC, may alleviate acute ethanol-induced hepatotoxicity by altering alcohol metabolic enzyme activities.
ABSTRACT<BR>INTRODUCTION<BR>MATERIALS AND METHODS<BR>RESULTS AND DISCUSSION<BR>ACKNOWLEDGMENTS<BR>REFERENCES<BR>
(0)
(0)