국가지식-학술정보
Silica Gel-Supported Polyphosphoric Acid (PPA-SiO<sub>2</sub>) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction
Silica Gel-Supported Polyphosphoric Acid (PPA-SiO<sub>2</sub>) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction
- 대한화학회
- Bulletin of the Korean Chemical Society
- Vol.32 No.2
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2011.01656 - 658 (3 pages)
- 0
커버이미지 없음
A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-$SiO_2$) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.
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