국가지식-학술정보
Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives
Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives
- 대한화학회
- Bulletin of the Korean Chemical Society
- Vol.35 No.2
-
2014.01617 - 621 (5 pages)
- 0
커버이미지 없음
An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.
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