국가지식-학술정보
Synthesis of Pyrazoloquinolines as Gastric <TEX>$H^+/K^+$</TEX>-ATPase Inhibitors
- 대한화학회
- Bulletin of the Korean Chemical Society
- Vol.19 No.6
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1998.01667 - 671 (5 pages)
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DOI : 10.5012/bkcs.1998.19.6.667
- 0
커버이미지 없음
A series of 1-aryl-lH-pyrazolo[4,3-c]quinolines and 2-aryl-2H-pyrazolo[4,3-c]quinolines are prepared by reacting 3-acyl-4-chloroquinolines in ethanol or 3-acyl-4(lH)-quinolone in acetic acid with appropriate hydrazines as possible anti-ulcer agents. A regiospecific synthesis of 1-aryl-lH-pyrazolo[4,3-c]quinolines is also achieved. The central pyridine ring could be easily reduced by catalytic hydrogenation.
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