여주열매 첨가식이가 당뇨 흰쥐의 지질과 항산화효소 수준에 미치는 영향

Effect of Dietary Supplementation with Bitter Melon on Lipids and Hepatic Enzyme Levels in Streptozotocin Induced Diabetic Rats

This study examined the effect of Momordica charantia L. (bitter melon: BM) on lipid and hepatic antioxidative enzymelevels in diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats by injection of streptozotocin (STZ), andrats were fed for 4 weeks with experimental groups divided into four groups: a normal control group, STZ-control and STZBM5% & STZ-BM 10% treated groups. Levels of free fatty acids (FFA), high-density lipoprotein cholesterol (HDL-chol),triglycerides (TG) in plasma and malondialdehyde (MDA) & protein in liver, catalase (CAT), superoxide dismutase (SOD),glutathione-S-transferase (GST), and xanthine oxidase (XOD) were measured in liver cytosol. Level of HDL-chol significantlyincreased in the STZ-BM 5% diabetic group. TG & FFA levels were significantly higher in all diabetic groups compared tothe control group. MDA and protein levels were significantly higher in the STZ-BM 5% group compared to all other experimentalgroup. CAT level was higher in the supplementary group with BM compared to the STZ-control group, although the differencewas not significantly different. SOD level was not significant in any experimental groups. GST level was significantly higherin the BM-treated groups compared to the STZ-control group. XOD level was significantly lower in the BM 5% group andsignificantly decreased in all experimental groups. These results show that supplementation of BM fruit powder may havebeneficial effects on diabetic complications and damage caused by oxidative stress.

This study examined the effect of Momordica charantia L. (bitter melon: BM) on lipid and hepatic antioxidative enzymelevels in diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats by injection of streptozotocin (STZ), andrats were fed for 4 weeks with experimental groups divided into four groups: a normal control group, STZ-control and STZBM5% & STZ-BM 10% treated groups. Levels of free fatty acids (FFA), high-density lipoprotein cholesterol (HDL-chol),triglycerides (TG) in plasma and malondialdehyde (MDA) & protein in liver, catalase (CAT), superoxide dismutase (SOD),glutathione-S-transferase (GST), and xanthine oxidase (XOD) were measured in liver cytosol. Level of HDL-chol significantlyincreased in the STZ-BM 5% diabetic group. TG & FFA levels were significantly higher in all diabetic groups compared tothe control group. MDA and protein levels were significantly higher in the STZ-BM 5% group compared to all other experimentalgroup. CAT level was higher in the supplementary group with BM compared to the STZ-control group, although the differencewas not significantly different. SOD level was not significant in any experimental groups. GST level was significantly higherin the BM-treated groups compared to the STZ-control group. XOD level was significantly lower in the BM 5% group andsignificantly decreased in all experimental groups. These results show that supplementation of BM fruit powder may havebeneficial effects on diabetic complications and damage caused by oxidative stress.