The effect of Hydroxyapatite/Chitosan (H/C) block scaffold and HA/β-TCP (H/T) particle on the regeneration wasevaluated in one-wall intrabony defects in beagle dogs. Six male beagle dogs were used in this study. H/C blockscaffold was manufactured by freeze-dried method. One-wall intrabony periodontal defects (4 × 4 mm) were surgicallycreated. Prepared defects were randomly assigned and treated as follows. In surgical control group (C) thedefects were not filled. In HA/β-TCP group (H/T), defects were filled with HA/β-TCP particle bone graft material. InHA/Chitosan block group (H/C), defects were filled with HA/Chitosan Block scaffold. In all groups, Mean values ofregenerated bone, regenerated cementum, connective tissue, and epithelium were measured. H/C group showedless inflammatory reaction than other groups. It revealed good biocompatibility. This group also showed bettercementum regeneration than any other group. However, due to the relatively rapid resorption of chitosan, spacemaintenance for regeneration seems to have been compromised. Bone regeneration was affected adversely with thisrapid resorption. More favorable bone regeneration was found in H/T group because proper space was maintainedwith Β-TCP.
The effect of Hydroxyapatite/Chitosan (H/C) block scaffold and HA/β-TCP (H/T) particle on the regeneration wasevaluated in one-wall intrabony defects in beagle dogs. Six male beagle dogs were used in this study. H/C blockscaffold was manufactured by freeze-dried method. One-wall intrabony periodontal defects (4 × 4 mm) were surgicallycreated. Prepared defects were randomly assigned and treated as follows. In surgical control group (C) thedefects were not filled. In HA/β-TCP group (H/T), defects were filled with HA/β-TCP particle bone graft material. InHA/Chitosan block group (H/C), defects were filled with HA/Chitosan Block scaffold. In all groups, Mean values ofregenerated bone, regenerated cementum, connective tissue, and epithelium were measured. H/C group showedless inflammatory reaction than other groups. It revealed good biocompatibility. This group also showed bettercementum regeneration than any other group. However, due to the relatively rapid resorption of chitosan, spacemaintenance for regeneration seems to have been compromised. Bone regeneration was affected adversely with thisrapid resorption. More favorable bone regeneration was found in H/T group because proper space was maintainedwith Β-TCP.
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