Treadmill exercise alleviates stress-induced impairment of social interaction through 5-hydroxytryptamine 1A receptor activation in rats

Treadmill exercise alleviates stress-induced impairment of social interaction through 5-hydroxytryptamine 1A receptor activation in rats

Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine ki-nase B (trkB), and cyclic adenosine monophosphate response element binding protein (CREB) have been suggested as the neurobiological risk factors causing depressive disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. We in-vestigated the effect of treadmill exercise on social interaction in rela-tion with BDNF and 5-HT expressions following stress in rats. Stress was induced by applying inescapable 0.2 mA electric foot shock to the rats for 7 days. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. Social interaction test and western blot for BDNF, TrkB, pCREB, and 5-HT1A in the hippo-campus were performed. The results indicate that the spend time with unfamiliar partner was decreased by stress, in contrast, treadmill exer-cise increased the spending time in the stress-induced rats. Expres-sions of BDNF, TrkB, and pCREB were decreased by stress, in contrast, treadmill exercise enhanced expressions of BDNF, TrkB, and pCREB in the stress-induced rats. In addition, 5-HT1A receptor expression was de-creased by stress, in contrast, treadmill exercise enhanced 5-HT1A ex-pression in the stress-induced rats. In the present study, treadmill exer-cise alleviated stress-induced social interaction impairment through enhancing hippocampal plasticity and serotonergic function in the hip-pocampus. These effects of treadmill exercise are achieved through 5-HT1A receptor activation.

Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine ki-nase B (trkB), and cyclic adenosine monophosphate response element binding protein (CREB) have been suggested as the neurobiological risk factors causing depressive disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. We in-vestigated the effect of treadmill exercise on social interaction in rela-tion with BDNF and 5-HT expressions following stress in rats. Stress was induced by applying inescapable 0.2 mA electric foot shock to the rats for 7 days. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. Social interaction test and western blot for BDNF, TrkB, pCREB, and 5-HT1A in the hippo-campus were performed. The results indicate that the spend time with unfamiliar partner was decreased by stress, in contrast, treadmill exer-cise increased the spending time in the stress-induced rats. Expres-sions of BDNF, TrkB, and pCREB were decreased by stress, in contrast, treadmill exercise enhanced expressions of BDNF, TrkB, and pCREB in the stress-induced rats. In addition, 5-HT1A receptor expression was de-creased by stress, in contrast, treadmill exercise enhanced 5-HT1A ex-pression in the stress-induced rats. In the present study, treadmill exer-cise alleviated stress-induced social interaction impairment through enhancing hippocampal plasticity and serotonergic function in the hip-pocampus. These effects of treadmill exercise are achieved through 5-HT1A receptor activation.