Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population

Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population

Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide poly-morphisms (SNPs) and the development, prostate volume, and international prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (As-p106Asp)] were genotyped and analyzed using multiple logistic regres-sion models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)=1.90, 95% confi-dence interval (CI)=1.07-3.41, P=0.03] and genotype frequencies (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contrib-ute to the disease severity of BPH.

Exercise has beneficial effect on cancer apoptosis and benign prostatic hyperplasia (BPH). The BH3 interacting domain death agonist (BID) gene expression is associated with apoptosis or cell proliferation. In this study, we investigated the association between BID single nucleotide poly-morphisms (SNPs) and the development, prostate volume, and international prostate symptom score (IPSS) of BPH. In 222 BPH males and 214 controls, two SNPs in BID [rs8190315 (Ser56Gly), and rs2072392 (As-p106Asp)] were genotyped and analyzed using multiple logistic regres-sion models. In the result, the genotype and allele frequencies of rs8190315 and rs2072392 were not associated with BPH development or IPSS, however, the allele frequencies [odd ratio (OR)=1.90, 95% confi-dence interval (CI)=1.07-3.41, P=0.03] and genotype frequencies (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) of rs8190315, and the genotype frequencies of rs2072392 (in dominant model, OR=1.94, 95% CI=1.01-3.74, P=0.42) were associated with increased prostate volume. We propose that rs8190315 and rs2072392 of BID may contrib-ute to the disease severity of BPH.