Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors
Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

한국응용생명화학회
Applied Biological Chemistry
Vol.52No.6
2009.01

735 - 738 (4 pages)
DOI : https://doi.org/10.3839/jksabc.2009.122

커버이미지 없음

외부링크

Anthranilic acid derivatives (3-5) containing the long chain components of N-stearoyl, -oleoyl, and -linoleoyl groups were synthesized for the study of prolyl endopeptidase (PEP, EC 3.4.21.26) inhibitory activity. Compounds 3-5 showed competitive PEP inhibition with $IC_{50}$ values of 2.81, 4.07 and 3.64 ${\mu}M$, respectively, and $K_i$ values of 1.62, 4.10 and 2.77 ${\mu}M$, respectively.

Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors
Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

(0)

(0)

(0)

(0)

Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

(0)

(0) 팝업 열기 팝업 닫기

(0)

(0)

Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors
Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

(0)