상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
133559.jpg
KCI등재 학술저널

DOCA-Salt를 이용한 SHR의 복합질환 모델 구축

DOCA-Salt를 이용한 SHR의 복합질환 모델 구축

  • 7

There are two types of hypertension such as primary or essential hypertension (90%) and the secondary makes up the rest. Even though, many intracellular signaling molecules may contribute to the cardiac hypertrophy as primarily or secondary regulatory molecule in spontaneously hypertensive rat (SHR), it remains unknown whether establishment of complex hypertensive animal model using deoxycorticosterone acetate (DOCA) in SHR is possible or not. Thus, the present study aimed to evaluate effect of the additional induction of hypertension using DOCA-salt in SHR. Strikingly, profound raised blood pressure were revealed in DOCA-WKY rat (71.5% vs. WKY) and DOCA-SHR (63.7% vs. SHR). Interestingly, the body weight as parameter following physiological growth were significantly decreased in DOCA-WKY rats (7.3% vs. WKY) as well as DOCA-SHR (6.9% vs. SHR). These results suggest that DOCA-SHR animal model might be available for investigation of incidental mechanisms between cardiogenic hereditary hypertension and secondary metabolic hypertension.

INTRODUCTION

MATERIALS & METHODS

RESULTS

DISCUSSION

REFERENCES

로딩중