Recently it has been shown in numerous experimental studies that a series of electroconvulsive therapy (ECT) affects neurohormonal function in man, though its mechanism was yet unknown. To investigate effects of methysergide on serum prolactin response after ECT, the authors studied the change of the serum levels of prolactin before ECT (the day before ECT) and after ECT, with and without methysergide pretreatment by RIA method in 11 psychiatric patients. ECT was given with the electrodes placed in the bitemporal position using a pulse current delivering device (Thy matron). The results were as follows ; 1) Compared with the day before ECT, serum prolactin levels were increased significantly at 15，30，60 minutes after ECT(P<0.01). 2) Compared with ECT alone, serum prolactin levels were attenuated significantly at 15，30, 60 minutes after ECT with methysergide (P 〈0.05，P <0.01). Hormonal responses of this study in terms of the knowledge availakle on the neurotransmitter control of prolaetin release suggests that the responses of prolactin to ECT may be mediated by the activation of serotonergic system in central nervous system.
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