정신분열병 환자의 면역기능에 관한 연구

A Study on Immune Function in Schizophrenia

This study was done to study immune function in schizophrenia focusing on lymphocyte, its subpopulations, natural killer cell activity and null cell. The subjects were 30 schizophrenic patients (male 19, female 11) according to DSM-III-R criteria, diagnosed by two psychiatrists They were admitted to Department of Neuropsychiatry, Presbyterian Medical Center and Sinsaeng Mental Hospital from February 1，1990 to September 30, 1990. The normal control group was 30 healthy volunteers(male 15, female 15) selected randomly. The results were as follows : 1) There was no significant difference between normal control and schizophrenic group in the number and percentage of lymphocytes (p〉0.05). 2) There was no significant difference between normal control and schizophrenic group in the number and percentage of T lymphocytes (p〉0.05). 3) The number and percentage of B lymphocytes ( t = &#8212;2.67，p < 0 .0 0 l) were statistically significant difference between normal control and schizophrenic group. 4) There was statistically significant difference between normal control and schizophrenic group in the number and percentage of null cells(t=2.59, p〈0.001). 5) There was no significant difference between normal control and schizophrenic group in helper to suppressor T cell ra tio (p > 0.05). 6) There was statistically significant difference between normal control and schizophrenic group in natural killer cell activities(t= &#8212;2.88, p〈0.05). 7) Sex difference of the number of lymphocyte in schizophrenic group ( t = &#8212; 0.30, p>0.05) was not statistically significant and that in normal control group ( t = &#8212;2.04，p〉0.05) was also not significant. 8) Positive and negative symptoms were not related in any way to the percentages of lymphocyte subpopulations, null cell and natural killer cell activities. ( p > 0.05). 9) There were inverse correlation between T and B lymphocytes and between T lymphocytes and null cells in both schizophrenic(N=30) and normal control g ro u p(N ^ 30) (p〈0.001). In conclusion, there are significantly different in some kinds of immune cell of the schizophrenic patients such as elevation of null cell and reductions of NK cell activity and B lymphocyte. The reduction of natural-killer cell activities is considerable, so authors feel this could be a biological marker for schizophrenia. However, role of antipsychotic medication in producing these changes is not clear.