정신분열병 양성 및 음성증상과 혈소판 Monoamine Oxidase 활성도

Platelet Monoamine Oxidase Activity and its Relationship to the Positive and Negative Symptoms of Schizophrenia

The intention of this study to investigate the relationship between the activity of platelet MAO and positive and negative symptoms in the male chronic schizphrenics by DSM-III. The authors devided the male chronic schizophrenics into positive, mixed and negative subgroups by Andreasen & Olsen Criteria(1982), and also each patient was evaluated in relation with positive and negative symptom scales proposed by Lewin & Meltzer( 1984) • The authors assayed kinetic constants (Vmax and Km) for platelet MAO from 22 drug-free schizophrenics and 22 normal controls, radioenzymatically using 14C-benzylamine as a substrate. The results were as follows ; 1) Schizophrenic subjects had a lower mean Vmax Value (5.20 ± 1.58 nmoles/108 platelets/hr) and Km value(38.92± 19.28X 1 0 6M ) for platelet M A O than normal c o n tro ls (8 .0 7 ± 4.54, 49.56土 18.48). Authough lower mean Vmax had a statistical significance, Km did not have. 2) In case of paranoid g r o u p (n = 6), there were no statistical differences in kinetic constants for platelet MAO compared with non-paranoid group(n=16). 3) There were no significant differences in kinetic constants for platelet MAO between positive, mixed and negative symptom group. 4) The difference between kinetic constants for platelet MAO and positive symptom scale and negative symptom scale were not significant statistically. 5) Each scale item in the negative symptoms was not significantlly different from platelet MAO activity. Finally, we confirmed that activity of platelet MAO was lowered in chronic schizophrenics, but we did not find any possible relationship between the negative symptom of schizophrenia and kinetic constants for platelet MAO