양극성 정동장애 및 정신분열증 환자군에서 성별에 따른 TRH 자극검사

The Relationship of Sex to TRH Stimulation Test in Bipolar Patients and Schizophrenics

This study was designed to evaluate the hypothalamic-pituitary-thyroid axis abnormalities and the possbible influence of gender on the TSH response to TRH in bipolar patients and schizophrenics by using TRH stimulation test. The subjects were consisted of 34 bipolar patients (male * 14，female * 20) and 24 schizophrenics( male * 11, female * 13). The results were as follows ; 1) There was a significant difference in the baseline TSH level of female subjects before TRH administration between bipolar patients and schizophrenics. 2) The TSH levels at 60 and 90 minutes after TRH administration in female bipolar patients were significantly higher from those of female schizophrenics(P〈0.05). 3) In female subjects, the response of TSH level after TRH administration was significantly different between the two groups(P<0.005)