조증 환자에서 Carbamazepine과 Lithium Carbonate의 갑상선 기능에 미치는 영향에 대한 비교

A Comparison of Effect on the Thyroid Function between Carbamazepine and Lithium Carbonate in Mania

The authors have studied on the thyroid function between carbamazepine and lithium carbonate in 35 manic patients. The thyroid function between level at baseline and level at week 4 were compared. The results were as follows &#8226;&#8226; 1) Carbamazepine g ro u p (N ^ 20) showed significant decrease in T 4(p<0.01)，Free T4(p〈0. 0005), T:3(p〈0.05), but no significant difference in TBG, and TSH. 2) For Lithium carbonate group(N = 15)，T4(p〈0.0005) and T3(p<〔0.05) were significantly decreased and TSH (p〈0.05) was significantly increased. 3) There was no symptom and sign of thyroid dysfunction in both groups during investigation period