This study was designed to investigate the therapeutic efficacy and adverse reactions of dothiepin. The subjects consisted of 40 patients diagnosed as major depression with DSMIII- R, who had been admitted to the Department of Neuropsychiatry, Kangnam St. Mary’ s Hospital, Catholic University Medical College from October 1，1989 to May 31，1990. Under double-blind conditions they were treated with either dothiepin or mianserin for a period of 4 weeks. Patients were assessed by Hamilton Depression Scale before treatment and after 1，2 and 4 weeks of treatment. The results were as follows • 1) A statistically significant improvement on the Hamilton Depression Scale was seen with both drugs after only one week’ s treatment(P〈0.001). 2) A comparison of the antidepressant effects of both drugs failed to show a statistical difference. 3) As for the side effects associated with dothiepin, constipation was the commonest, followed by dry mouth, urinary retention, and drowsiness. However, the anticholinergic effects of dothiepin were mild, and by indirect comparison, dothiepin seemed to have fewer side effects than amitriptyline. In view of our results, dothiepin was found to be an effective antidepressant agent
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References