뇌 전산화 단층촬영상 정신분열증 환자의 대뇌반구 비대칭의 반전에 관한 연구

A Study o f Reversed Cerebral Asymmetries on Computed Tomographic Scans in Schizophrenic Patients

Right handed normal person tend to show neuroanatomical asymmetries of the brain on CT, with larger Rt. Frontal and Lt. occipital lobe than the respective contralateral structu-res The authors examined the frequency of reversals of this normal asymmetry in group of 32 right handed schizophrenic patients. Compared to 22 normal right handers, the schizophrenics had an increased frequency of both frontal and occipital reversals, especially occipital reversals(p〈0.05). The authors then divided the patients into two groups on the basis of whether they had CT evidence suggestive of brain atropy or not. But there was no significant differences in the frequency of reversals. Patients with frontal reversal only had earlier onset, shorter duration of hospitalzation and of drug uses, and smaller doses of antipsychotic drugs than patients with occipital reversal. This findings suggest that schizophrenic patients with frontal reversal only may have a milder clinical course than patients with occipital reversal.