In order to elucidate the mechanism of action of electroconvulsive shock (ECS) in psychiatric illness, the author investigated the effect of electroshock on glutamine synthetase (GS) in rat brain. GS activities in hippocampus, corpus striatum and cerebral cortex were measured after single, multiple and regressive electroshocks (subconvulsive and convulsive doses) to normal rats, and GS activities were also measured after ECS in methionine sulfoximine treated rats. Major findings were that ten daily ECS (multiple ECS) decreased GS activities in the hippocampus and four ECS in 30 min interval (regressive ECS) reinforced the GS inhibition of methionine sulfoximine. These findings suggest that GS may play a significant role in the mechanism of action of ECS and need further studies.
서 론
연구재료 및 방법
연구성적
고 찰
결 론
References