In an attempt to identify some of the biochemical processes underlying immobility in rats, the authors investigated the effects of a variety of pharmacological agents known to modify neurotransmission in central noradrenaline, dopamine and serotonin systems. The results suggest that immobility is sensitive to agents which modify the activity of central catecholamines but is insensitive to agents which act primarily on serotonin. And, several investigations have suggested a special relationship exists between thyroid function and affective disorders. Given the activity of T3 on psychopharmacological models of depression in rodents, we also investigated the effects of T3 on behavioral tests in rats. The present study shows that the reversal by amitriptyline of depressive-like behavior in rats was markedly potentiated to T3 administration. This supports notion of intricate thyroid and CNS interaction in the mechanism of action of antidepressant, especially by serotonergic system.
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