To investigate the characteristic features and the diagnostic meaning of the cognitive evoked potential in schizophrenics, the authors performed the auditory evoked potential to the schizophrenic patients(n=34) who were admitted to Seoul National University Hospital and the normal controls (n=19) from the 15th, Feb. 1988 to the 24th, Aug. 1989. The latency and peak-to-peak amplitudes of the cognitive evoked potentials were compared with student t-test between schizophrenic group (n 그: 19) and control group who was age-and sex-matched by one to one. Also, the correlations between 12 items of clinical characteristics, and latency and peak-to-peak amplitudes were studied in schizophrenic group(n=34). The schizophrenic group showed longer latencies in N2 and Pa and smaller amplitude in P3-N3 than the control group, and there were the statistically significant correlations between age of onset and P2-N1 amplitude, between number of the electroconvulsive therapy and P3-N3 amplitude, between the presence of the auditory hallucination and the P1-N1 amplitude, between the medication dosage at test and amplitudes of P3-N2, P3-N3 and Ni latency, and between years of education and amplitudes of P1-N1, P2-N2 and P2-N1. We confirmed that there were some differences of the cognitive evoked potentials between schizophrenic patients and normal controls. Also there were some clinical characteristics which had influences on the cognitive evoked potentials. We discussed the possibility of cognitive evoked potenlials as diagnostic utility. For that, study condition needs to be controlled and standardized, and the basic psychophysiological study of cognitive evoked potentials should be preceded.
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