Lithium과 항정신병 약물의 병합치료에 의하여 발생된 급성 뇌증후군

Acute Organic Brain Syndrome due to Combined Use of Lithium and Neuroleptics

The authors studied the characteristics of the acute brain syndrome induced by lithium-neuroleptic combined treatment in manic patient, admitted to the Neuropsychiatric Department of Kang-Nam St. Mary’s Hospital from January 1981 to December 1987. Among 204 manic patients who had been treated with lithium and neuroleptics, 9 subjects showed acute brain syndrome. The charateristics and risk factors of acute brain syndrome subjects were analyzed, and the results were as follows; Acute brain syndrome appeared within 2 weeks follwing combined therapy of lithium and neuroleptics, even though serum lithium level were maintained within therapeutic ranges. Following the discontinuation of the drugs acute brain syndrome completely disapperared within 1 week. This findings strongly suggest that the acute brain syndrome seems to be an idiosyncratic response to the lithium-neuroleptic interaction.