가족력이 있는 만성정신분열증 환자의 인간조직적합성 항원 (HLA)

HLA Antigens in Chronic Schizophrenic Patients with Family History of Schizophrenia

The authors studied the frequencies of HLA antigens (A, B, C and DR) in 20 chronic schizophrenic patients who had one or more schizophrenic patient (s) among their first degree relatives. The data of these study subjects were compared with those of patient controls and normal controls. The patient controls were composed of 20 chronic schizophrenic patients who had no family history of schizophrenia. HLA-A, B, C antigens of normal controls came from 196 healthy Korean volunteers and HLA-DR antigens came from 205 healthy Korean volunteers. The diagnoses of schizophrenics were made according to RDC and Family History-RDC. The results were as follows : 1) The frequencies of B5i, Beo, DR3 and DRs antigens were significantly higher in total schizophrnic patients than the control group. 2) The frequencies of A3, An, and Beo, DRg antigens were higher in schizophrenic patients with family history than the control group. Especially, the frequency of DR antigen was the highest. 3) The frequencies of B5i, C7, DR2, and DRs antigens increased significantly in schizophrenic patients without family history. 4) DRg is the only antigen that showed significantly higher frequency in patients with family history than those without one. 5) Consequently, these results suggest that DR« locus is probably related to genetic or biological marker of Korean familial chronic schizophrenics.