In order to investigate the relationship between the schizophrenia and altered immunity a study on the lymphocyte function and subpopulation in the schizophrenic patients was attempted. The authors measured percentages and numbers of the T lymphocyte and B lymphocytes in 17 schizophrenic patients and 16 healthy volunteers by using the monoclonal antibody technique. The findings are as follows : 1) Compared to the normal control group, there were no significant difference in schizophrenic group in the number and percentage of T lymphocytes. The percentage and number of T lymphocytes were 56.3± 9.14 %，1193± 288/mm3, in normal control group and 56.4±5.97%, 1277± 344/mm3 in schizophrenic group. 2) Compared to the normal control group, schizophrenic group were significantly higher in the number and percentage of B lymphocyte. The percentage and number of B lymphocyte were 18.0± 6.65%, 408± 193/mm3 in normal control group and 28.2±8.89%, 598± 206/mm3 in schizophrenic group(p〈0.01). 3) Increased number and percentage of B lymphocyte in schizophrenic group might support the immune theory of the schizophrenia that schizophrenia is caused by autoimmune process or slow-virus infection, but, in this study, we could not eliminate the effect of psychotropic drugs and the stress on the lymphocyte in the patient group.
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