Although nuclear tomography had begun in 1959 by Kuhl, investigators has been interested in the SPECT since 1970s. Among various radionuclide tracers, technetium(Tc99m) has been known to be more available because it can be easily permeable through the blood-brain barrier, adequately retentive, and widely usable in the clinical field because of it’ s lower costs than the positron emission tomography (PET). So, 99m Tc-HMPAO SPECT has been used in the studies on cerebrovascular diseases, dementias, epilepsy, tumor, migraine, schizophrenia, alcoholism and affective disorders, etc. In the epilepsy, it was reported that the cerebral blood flow was increased during ictal phase, but decreased during interictal period, while others insisted of interictal hyperperfusion due to subictal neuronal hyperactivity. We compared the cerebral blood flow of 17 epileptics with that of 12 neurotic controls measured by 99m Tc-HMPAO SPECT to observe the perfusion change in the interictal phase. The results were as follows : 1) Compared to the controls whose activity counts per frame were decreased to 5.5±3.3^ (mean士 S.D.), 29.4% of epileptics showed hyperperfusion to 10.9± 7.2%(p〈0.05), and 70.6% showed hypoperfusion to 10.8± 3 .3 ^ (p〈0.001). • 2) Most of foci of maximal blood flow change were located at the right hemisphere and posterior part. The foci in the anterior part could be found more in controls(33.3 % )，while posterior foci in epileptics(88.2 % ; hyperperfusion group 80.8 %, hyoperfusion group 91.6%) without statistical significance. 3) The degree of EEG abnormality was not correlated with the activity counts per frame. Abnormal findings were more frequently seen in the hyperperfusion group(80.8 %) than in the hypoperfusion group(41.7 % ) without statistical significance. The abnormal findings are mostly composed of high voltage(88.9 % ), and spike with or without wave(50.0 %) or slow wave only (50.0 %) without correlation with the activity counts per frame.
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