The authors have studied on the antimanic and hematological effects of carbamazepine on twenty cases of manic patients. Thirteen of twenty manic patients showed rather favorable responses, from moderate to marked degree. Significant decreases on the BPRS(Brief Psychiatric Rating Scale) and Ms (Mania-State Rating Scale) score appeared as fast as within three days after starting carbamazepine treatment. Carbamazepine was found to cause statistically significant, but clinically insubstantial, decreases in white cell indexes. The consistent decreases in white cell counts observed withcarbamazepine treatment should be differenctiated from the extremely rare, idiosyncratic blood dyscrasias previously reported in the literatures. There were no significant side effects except two cases of dropout during carbamazepine treatment. These results suggest that carbamazepine is useful in treating manic patients.
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