Most clinicians agree that the group of disorders called schizophrenia is heterogeneous. Since Kraepelin described dementia praecox, various attempts have been taken to subdivide schizophrenia into several homogeneous subtypes. Recently some investigatiors were interested in the division of schizophrenia by use of positive & negative symptomatology that Hughlings-Jackson had tried. Crow especially hypothesized that there were some differences between the tow prominent symptoms(negative & positive) in respect of premorbid adjustment, response to neuroleptic therapy and underling pathologic process etc But this hypothesis remains largely untested. Using Andreasen & Olsen’ s criteria for negative, positive and mixed schizophrenia, we subdivided a consecutive sample of 67 schizophrenic patients into 3 subtypes (negative 21, positive 23, mixed 23). We then evaluated some characteristic aspects among these 3 subtypes. The results are as follow • 1) There was s significant difference in mean age among the three subtypes. In the negative group, the mean age was most high and this was followed by the positive group(p<C0.05) 2) There was a significant difference in the duration of education among the three subtypes. In the negative group, the duration of education was least and this was followed by the positive group(p<0.05). 3) There was a significant difference in premorbid adjustment among the three subtypes. The level of premorbid adjustmentwas lowest in the negative group and this was followed by the positive group. (p<0.005). 4) There was a significant difference in the number of previous hospitalizations among the three subtypes. In the negative group, the number of hospitalizations was lowest and this was followed by the positive group.(p<C0.005). 5) The experience of previous modem psychiatric treatment was more reare in the negative group and this was followed by the positive group.(p<C0.05). 6) The score of mini mental status for evaluation of cognitive function was significantly lower in the negative group and this was followed by the positive group.(p<C0.00l). 7) The scores of the BPRS for evaluation of psychotic symptoms at the times of admission and 4 weeks later were significantly most high in the positive group and this was followed by the mixied group (p<0.05, respectively). The therapeutic response rated on the BPRS after 4 weeks, was significantly prominent in the positive & mixed groups(p<C0.05, respectively), but not in the negative group. 8) Besides these, there were no significant differences in occupation, onset of age, duration of illness and family history among the three subtypes.
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