Lithium 의 혈중농도와 치료효과

Serum Lithium Level and Clinical Effects

S e rum lith iu m le ve l an d c lin ic a l efficacy w e r e s t u d i e d r e t r o s p e c t i v e l y w i t h 4 8 m a n i c p a tie n ts d iag n o se d a c c o rd in g to D SM 1 criteria T he re sults were as fo llow s; 1) T he n u m b e r of to ta l re sponder was 38 a n d th e efficacy rate was 79.1% , b u t the seru m lith iu m le ve l o f re sponder w as w ide ra n g e betw een 0 .4 - l,5 m E q /L . 2) It to o k in average 7days to reach th e so - calle d steady state o f serum lith iu m le ve l b e tw e e n 0.6—L 2 m E q /L . 3) It took 2 weeks to reach to 50 G A S score a n d revealed 0.701:0.28m E q/L serum lith iu m le v e l, 1102± 262m g/day lith iu m dosage. A t 3 w eeks, it revealed 59.94± ： 11.89 G A S , 0.6±021 m E q /L serum lith iu m leve l, 1135士33 3m g /day lith iu m dosage. A lso at 4 weeks, it revealed 65.47±10그 1 G A S , 0.66± O ^O m E q /L serum L ith iu m leve l, 1125± 341 m g /d a y lith iu m dosage. Our results suggest that lithium carbonate was effective to treatment of mania and signi- ficant positive correlation was obtained be-tween serum level and clinical efficacy but serum lithium level alone is not crucial pre dietor to determine the clinical efficacy. So, further study such as RBC /plasma lith ium ratio is needed to prove the valuable predictor of the response to lithium in mania.