정신분열장애에서의 혈소판 및 혈장 Amine Oxidase 활성도

Platelet and Plasma Amine Oxidase Activity in Schizophrenic Disorder

For the purpose of evaluating possible linkage between alcoholism and depression, dexamethasone suppression test (DST) was performed to 15 alcoholics, 8 major depressives, and 11 non-depressive psychiatric inpatients. The alcoholics were tested twice ; in the intoxicated and recovered state. Dexamethasone suppression Test(DST) using 1 mg of dexamethasone was performed in 49 subjects, and serum cortisol concentration was determined by radioimmunoassay using the Coat-A-Count Procedure. The results were as follows; 1) Basal serum cortisol levels were higher in the major depressives and the alcoholics than in the non depressive psychiatric inpatients. 2) Post-dexamethasone serum cortisol levels were also higher in the major depressives and the alcoholics than in the non-depressive psychiatric inpatients. 3) Basal serum cortsol levels of the intoxicated and recovered alcoholics were proved to be equally elevated, comparing with those of the non-depressive inpatients. 4) Non-suppressor of DST was detected none of the non-depressive inpatients, in 25% of the major depressives, 20% of the intoxicated alcoholics and in 33.3% of the recovered alcoholics. With the above results, the authors could suggest the possibility that there are considerable cases of primary depression among the alcoholics.