외상후 자극장애 환자의 국소대뇌혈류

Regional Cerebral Blood Flow in Patients of Post-traumatic Stress Disorder

The authors checked regional cerebral blood flow by the application of Xenon 133 inhalation method to 17 patients who were admitted to the dept, of neuropsychiatry, Seoul Paik hospital. All of the patients had been injured on the head after 1983 year and they did show no special abnormal findings on any neurological evaluations, including computerized tomography of the head, electroencephalography and other neurological examinations. They were diagnosed by DSM III criteria as posttraumatic stress disorder on admission. As the treatment had been processing, we found that they had not good response to various neuropsychiatric treatments and showed a lot of symptoms similar to organic brain syndrome such as failure of impulse control, concentration and memory difficulties, social withdrawal and emotional shallowness. The results were as follows; 1) According to Fi and ISI, total mean value and right and left hemispheric mean value of the patients were in normal range. 2) We compared Fi of the patients with normal control group, frontal, parietal, occipital lobe flow of the patients were increased and temporal lobe flow of the patients were decreased than normal group without statistical significance. In case that we compared ISI of the patients with normal group, frontal, temporal lobe flow were increased and parietal lobe flow were decreased than normal group without statistical significanc 3) According to comparing the Fi of regional CBF with one of the total mean CBF in the patients, frontal lobe rCBF were increased (p< 0.001) and temporal, parietal, occipital lobe rCBF were decreased (p<0.05) with statistical significance. In case of comparing ISI of rCBF with one of the total CBF in the patients, frontal lobe rCBF were increased (p<0.05) and right temporal, parietal, occipital lobe rCBF were decreased (p<0.05) authors suggest that if we experience patients who have similar characteristics with above mentioned symptoms, it may be helpful to us to check rCBF in order to find with statistical significance. organic sign and to decide diagnosis and prognosis.