慢性 精神分裂病에서 Penfluridol이 血淸 Prolactin 値에 미치는 影響

The Effect of Penfluridol on Serum Prolactin Levels in Chronic Schizophrenia

The experiment was aimed to study the prolactin response induced by long acting oral antipsychotics, penfluridol in 17male chronic schizophrenics^ After one week wash out period of other neuroleptics, penfluridol was administered orally with increment of 20 mg per week, and serum prolactin level was measured by the method of radioimmunoassay at the interval of 1, 2, 3, 4, 5 and 6 weeks after administration of penfluridol The results are as follows : 1) After one week washout period of other neuroleplics, the mean serum prolactin level was measured as 13.9± 8.57 ng/ml. ^ The mean serum prolactin levels after administration of 20 mg, 40 mg, and 60 mg of penfluridol were 24.3± 11.89 n g/m l, 38.1 ±20.66 n g /m l， and 56.1 ±25.47 n g /m l respectively. These rapid increases of prolactin secretion were statistically significant ( P <0.005). 3) The mean serum, prolactin levels after administration of 80 mg and 100 mg of penfluridol were 63.9± 27.45 ng / ml and 69.4± 29*83 ng /m l respectively- These increases showed less higher increase than those of administration of 20 to 60 mg of penfluridol. ridoL 4) The clinical symptoms were sli^idy improved, but those were not as much as increase of serum prolactin levels. As the above results, it was known that the pen fluridol was effected serum prolactin levels for 1week.