Lorazepam 과 Diphenhydramine 의 추체외로증후군에 대한 효과비교

Comparison of the Effects between Lorazepam and Diphenhydramine for Extrapyramidal Symptoms

In this study, a comparative evaluation on clinical efficacy between intravenous lorazepam and diphenhydramine for extrapyramidal symptoms occurring on neuroleptic therapy was made. Subjects were consisted of 42 cases in cluding 8 males and 34 females. They were under double - blind procedure, given single injections o f 4 miligrams of lorazepam ( 21 cases) and 50 miligrams of diphenhydramine ( 21 cases) seperately. The effects were evaluated by Extrapyramidal Symptoms ( EPS ) Rating Scale for extrapyramidal Symptoms as well as by the Brief Psychiatric Rating Scale ( BPRS ) for psychotic symptoms and signs. The results were as follows : 1) Most of extrapyramidal symptoms induding parkinsonian symptoms, akathisia and dystonia were noted to be significantly improved 60 minutes after injection on EPS Rating Scale scores. 2) BPRS evaluation 60 minutes after injection resulted in significant reduction of the total mean scores in both groups, although no significant difference can be made in terms of efficacy between the group when the two groups were compared. 3) Clinically it can be suggested that the seda-tive effect of diphenhydramine was less than that of lorazepam. The above mentioned results suggest that lorazepam and diphenhydramine may well be the drugs of choice for the treatment of extrapyramidal symptoms occurring on the neuroleptic therapy.