Thirty male schizophrenics admitted to the Seoul National Mental Hospital between March 20, and July 11,1985，were studied for 4 weeks on the correlation between 9cmm prolactin levels and clinical improvement. On admission, the baseline serum prolaction levels were determined by double antibody radidmmunoassay method, the baseline rating oi Psychopathology were done by two raters using BPRS. According to the severity of clinical symptoms, all the patients were administered haloperidol of variable dosage. Follow - up serum prolactin levels and BPRS rating were done at 1st, 2nd, 4th week, the results are as follows. 1) Serum prolactin levels and BPRS total scores showed statistically significant changes prop*ortional to daily haloperidol dosage in the 1st, 2nd, 4th week (1st week : P <0.05, 2nd & 4th week : p <0.01) Significant improvement were observed in BPRS subscales, thought disturbance and paranord disturbance in the 2nd & 4th week and in withdrawal retardation in the 4th week. 2) The correlation between daily haloperi dol dosage and serum prolactin levels was not significant. The correlation between serum prolactin levels and BPRS total scores was significant in the 1st week ( P <005 ). There were statistically significant correlations between a BPRS subscale, par an id disturbance and serum prolaction levels in the 2nd & 4th week ( P <0.05 ) 3) Mean changes of daily haloperidol dosage, serum prolactin levels and BPRS total scores sho* wed statistically significant difference in the 4ht week ( P <0.01 ). Significant changes were observed in two BPRS subscales, thought disturbance and paranoid disturbance in the 2nd & 4th week (thought disturbance in the 2nd & 4th week, para-noid disturbance in the 4th week, paranoid dis-turbance in the 4th week: P <0.01, Paranoid distu-rbance in the 2nd week: P <0.05 > 4) The correlation between changes of serum prolactin levels and a BPRS subscale,withdrawal retardation was significant ( r= —0.404, P <0.05 ). 5) The Serum Prolactin levels & the changes of them between improvement group in BPRS (above 20 Points, N — 8 ) and non- improve - ment group in BPRS (below 10 Points,N =9) were not significant 6) The serum Prolactin levels and the changes of them between the drug free group (N =9 > and the antipsychotics treated group for over 2 years ( N —8 ) were not significant.
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