Alprazolam 의 항불안 및 항우울 효과에 대한 이중맹 치험

A Double Blind Clinical Study on Antianxiety and Antidepressant Effects of Alprazolam

Forty —seven out patients with generalized anx- iety disorder by DSM - III criteria were randomly assigned to receive ether alprazolam or placebo. The dosage of alprazolam was 1.5 to 2.0 mg per day and treatment period was 2 weeks. Clinical evaluation with Hamilton’s anxiety scale and depression scale were done on the double blind basis before( baseline} and after treatment. The changes from baseline were compared between placebo and active dm.g groups. The result of study showed that alprazolam produced significantly more clinical improvement than did placebo in both anxiety and depression The side effects as anticholinergic effects were not reported for alprazolam as well as placebo. To-lerance and withdrawal symptoms were not noted during the study period of 4 weeks,