1) Intraventricular DMI(300ug,lmg) produced a hypotensive response in urethane-anesthetized rabbits, howeber In travenous DMI produced no distinctive effect. 2) The hypotensive effect of DMI was inhibited by treating rabbits with intraventricular yohimbi-ne or piperoxan, whereas intaventricular prazosin did not affect the effect. 3) The hypotensive effect of DMI was not produced in clonidine-hypotension rabbits and the hypotensive effect of olonidine was weakened in DMI-hypotension rabbits. 4) In reserpine pretreated rabbits intraventricu-lar DMI (300ug, lmg) produced a hypertensive respones, which was not affected by treating the rabbits with yohimbine but was inhibited by pra zosin. 5) Intraventricular norepinephrine produced little pressor effect in the rabbits pretreated with 300ug of intraventricular DMI, but it produced marked pressor effect after lmg of intraventricular DMI. 6) Intraventricular protriptyline did not cause hypotension. 7) It is inferred that intraventricular DMI produced a hypotensive response in rabbits by acting on a2-adrenoceptors, and this was not associated with the inhibitory effect of DMI on norepinephrine up take in adrenergic neurons.
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