The purpose of this study was to test the antipsychotic effect of diazepam. Twenty-five hospitalized chronic schizophrenic patients who had been resistant to standard neuroleptic treatment were included. The patients were subdivided into two groups and the study was run double-bline, cross-over, with twc successive periods of three weeks each. Thus all patients were received once diazepam (30〜90mg/day) and once placebo alternatively. The effect of diazepam was assessed weekly by the Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impression Scale (CGI). Diazepam showed no difference from placebo in antipsychotic effect during total six weeks, that is, two successive periods of three weeks, but there were significant antipsychotic effect of diazepam, during first three weeks. This result seems to be due to the carry-over effect of diazepam during second three weeks for placebo medication and due to the masking of antipsychotic effect by the side effects of diazepam. So further longterm clinical studies are needed. In addition, there were no significant differences in sex, age, duration of illness, maintenance daily dosage of diazepam, neuroleptic dosage and duration of neuroleptic medication over chlorpromazine 600mg equivalent between the patients who did respond to diazepam and who did not. Eight patients dropped out mainly because of the side effects. Seventeen patients completed this study and ten of them showed the side effects during the maintenance periods of diazepam.
서 론
방 법
결 과
고 찰
결 론
REFERENCES