정신분열증 환자의 혈청 총 CPK 활성치 및 동위효소의 분획상

Total Serum CPK Activity and the Isoenzyme Fraction in the Schizophrenic Patients

The purpose of this study was to determine the total serum CPK activity and the fractions of the isoenzymes in the schizophrenic patients and to investigate the correlation between the CPK activity and several clinical variables such as symptoms, course, subtype of schizophrenia. 18 hospitalized schizophrenic patients and 9 healthy adult controls were subjects of this study. The results were as follows; 1) Total serum C PK activity of all the normal controls fell in the normal range but that of 3 schizophrenic patients exceeded the normal range. Means of total ssrum C PK of both groups were in the normal range, but that of the schizophrenic group was significantly higher than that of the control group by 59. 1±23. 2 I.U./7 vs. 45. 0±9. 1 I.U .//. 2) Mean value of the M B type isoenzyme of the schizophrenic group was 6. 1±3. 9 I.U .//, a significantly higher level than that of the control group in which the value was 1. 4±1. 1 I.U .//. Mean of . MM type isoenzyme of the schizophrenic group was 49.7±20. 7 I.U // and that of control group was 43. 6±8. 6 I.U .//, showing no significant dif- ference. The BB type was detected in 3 schizophrenics and in none of the control group. 3) The correlation coefficients calculated between the total serum CPK activity and 16 symptom cate-gories of the Psychiatric Evaluation Form of Spitzer et al excluding 3 symptom categories of Narcotics-Drugs, Antisocial Attitudes-Acts, and Alcohol Abuse revealed significantly high correlation in the symptoms of Social Isolation, Belligerence- Negativism and Disorientation-Memory. The remaining items of Agitation-Excitation, Suicide- Self Mutilation, Grandiosity, Somatic Concern, Speech Disorganization, Hallucination, Anxiety, Inappropriateness, Suspicion-Persecution, Denial of Illness, Depression, Daily Routine-Leisure Time and Retardation-Lack of Emotion did not correlate with the CPK activity. No significant difference was noted between paranoid and non-paranoid schizophrenics and between the groups of long and short durations of the active symptoms. From the above results, the authors could confirm the elevation of the total serum CPK activity in the schizophrenics as compared to the normal controls. They also suggest further probing into the alterations of the isoenzymes with sufficient number of the subjects and with more refined procedures.