정신분열병 환자의 혈청과 뇌척수액의 동 및 아연농도에 관한 예비적 연구

A Preliminary Study on Copper and Zinc Concentrations in Serum and CSF of Schizophrenia

To investigate copper and zinc concentrations in schizophrenia, we have measured copper and zinc concentrations in the serum and CSF of 27 male schizophrenia (mean age 30. 2 ±5. 6) and 10 male controls (mean age 42 7 ±10. 6) w ith atomic absorption spectrophotometry. The results were as follows; 1. There were no significant differences in serum and CSF copper concentrations between groups of controls, unmedicated schizophrenic patients, and schizophrenic patients taking neuroleptics. Neuroleptics did not significantly alter mean copper concentrations in serum and CSF of schizophrenic patients. 2. There were no significant differences in serum and CSF zinc concentrations between groups of controls, and schizophrenic patients. B u t mean CSF zinc concentration was lower in a group of 3-week-drug-free schizophrenic patients. 3. Neuroleptics did not significantly alter mean CSF zinc concentrations of schizophrenic patients, but serum zinc concentrations were influenced by neuroleptics. 4. There were no significant correlations between CSF copper (or zinc) concentrations and serum copper: (or zinc) concentrations in schizophrenic patients or controls.