Lithium Carbonate가 白鼠 臀臟에 미치는 影響에 關한 電子顯微鏡的 硏究

Electron Microscopic Study on Rat Kidney Cells after Lithium Carbonate Administration

To investigate the effects of lith ium carbonate on rat (Sprague-Dawley) kidney cells, light and electron microscopic observation were made. Experimental rats received daily intraperitoneal injections of lithium carbonate in doses of 30 or 150mg/kg. These animals were killed on 6.13. 20. 30 days after the first injection. 1) In the distal convoluted tuble, the 30mg/kg lithium carbonate dosages caused progressive mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, generalized reduction of cell organelles, irregular basal infolding and dilatation of Golgi apparatus. In the proximal tuble, same, dose of lithium carbonate caused appearance of lysosomes, mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, and appearance of dense bodies. These cellular changes were more marked with the lapse of time. 2) In the distal convoluted tuble, the I50mg/kg lithium carbonate dosages produced destruction of basal infolding (which was more severe compared with those 30mg/kg dosage), many vesicles in cytoplasm and cytoplasmic swelling. In the proximal tuble, the same dosages of lithium caused appearance of lysosome, mitochondrial swelling, loss of mitochondrial crest, appearance of many vesicles. These celluar changes were also more marked with the lapse of time. The present study demonstrated th at usual dosage of lithium carbonate do affect the stru-cture of the rat kidney.