Nitrazepam is one of 1,4-benzodiazepin derivatives widely used as a hypnotic in clinical medicine. Chemically it is 1,3-dihydro-7-nitro-5-phenyl-2H- 1, 4-benzodiazepine-2-one. The sedative and anticonvulsant effects of nitrazepam on experimental animals resemble those of other benzodiazepines. It also proved to be effective in the treatment of enuresis. But it is used as a safe and potent hypnotic rather than as an anxiolytic agent. Investigators suggested that any new psychotropic drugs should be tested for their interaction with alcohol, because they might precipitate adverse reaction if consuming them concurrently. In view of these facts, the author conducted an animal experiment to investigate the effects of nitrazepam on blood alcohol level in rabbits. The experiment was done on mature rabbits of both sexes. The control group was given alcohol alone, and the experimental groups was given no only alcohol but also various oral doses of nitrazepam, namely 5mg/kg for 5days, 5mg/kg for lOmg/kg for 5days and 10mg/kg for lOdays, respectively. The last dose was given one and a half hour before alcohol administration. In all groups, 5mg/kg of 20% ethanol solution was given intravenously and at 15 and 45 minutes after alcohol injection blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. Blood alcohol levels at both 15 and 45 minutes after alcohol administration were not significant differet between control and experimental groups injected with 5mg/kg for 5days and 10mg/kg for 5days. But there was significant difference between control and experimental groups injected with 5mg/kg for lOdays and 10mg/kg for lOdays in blood alcohol level at both 15 and 45 minutes after alcohol administration (P < 0 .001, <0.001 and P〈 0.01, <0.001, respectively).
서 론
실험재료 및 방법
실험 결과
고 찰
결 론
REFERENCES