Zizyphus semen have been utilized for thousands of years in the Far East and India as sedati ves. The author conducted and animal experiment to investigate the effects of this semen on blood alcohol level, because many investigators have suggested that any new psychotropic drug should be tested for their interaction with alcohol. The experiment was done on mature rabbits of both sexes. The control group was given alcohol alone. The experimental groups were given intravenous doses of water soluble extractions of zizyphus semen, that is, 3ml/kg for 5 days, Sml/kg for 10 days, 5ml/kg for 5 days, and 5ml/kg for 10 days, respectively before alcohol administration. The last dose was given one and a half hour before alcohol administration. In all groups, 5ml/kg of 20% ethanol solution was given intravenously. And at 15 and 45 minutes after alcohol injection, blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. When comparing with the control group, zizyphus semen, when given 3ml/kg for 5 days and 10 days, elevated the bleed alcohol level significantly at 15 minutes after alcohol administration but not at 45 minutes. And zizyphus semen, when given 5ml/kg for 5 days and 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.
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